SATA

SATA
N-Succinimidyl S-Acetylthioacetate
Product Number: PM108
CAS# [76931-93-6]

Molecular Weight: 231.22
Melting Point: 95 °C
Spacer Arm: 2.8 Â

Adds protected sulfhydryls for better control when a sulfhydryl group is needed in conjugate formation.

Features/Benefits:
– Reacts with amines to add protected sulfhydryl groups
– NHS ester end couples with primary amines at pH 7-9 to form stable amide bonds
– Converts amino groups to sulfhydryl groups
– Latent -SH group is released by hydroxylamine and is available for reaction with maleimide- activated biomolecules or other -SH group-containing compounds
– Cross-links formed with other -SH group-containing molecules are reversible by reducing agents
– Reactive groups: NHS ester and thioacetylprotected sulfhydryl
– Reactive toward: amino and maleimide/iodoacetyl or vinyl sulfone

Reference: Duncan, R.J.S., et al. (1983) Anal. Biochem. 132, 66-73