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SATA | Campbell Science
SATA | Campbell Science


SDS & Associated Documents

  •   SATA Safety Datasheet

N-Succinimidyl S-Acetylthioacetate
Product Number: PM108
CAS# [76931-93-6]

Molecular Weight: 231.22
Melting Point: 95 °C
Spacer Arm: 2.8 Â

Adds protected sulfhydryls for better control when a sulfhydryl group is needed in conjugate formation.

- Reacts with amines to add protected sulfhydryl groups
- NHS ester end couples with primary amines at pH 7-9 to form stable amide bonds
- Converts amino groups to sulfhydryl groups
- Latent -SH group is released by hydroxylamine and is available for reaction with maleimide- activated biomolecules or other -SH group-containing compounds
- Cross-links formed with other -SH group-containing molecules are reversible by reducing agents
- Reactive groups: NHS ester and thioacetylprotected sulfhydryl
- Reactive toward: amino and maleimide/iodoacetyl or vinyl sulfone

Reference: Duncan, R.J.S., et al. (1983) Anal. Biochem. 132, 66-73